Based on the information available, it is not recommended to take Lipitor and St. John's Wort together. Lipitor, a medication used to treat high cholesterol, can interact with St. John's Wort, a dietary supplement used for depression and anxiety [1].

St. John's Wort can decrease the effectiveness of Lipitor by increasing the activity of certain liver enzymes that break down Lipitor in the body [1]. This can lead to reduced levels of Lipitor in the blood, which may decrease its effectiveness in lowering cholesterol levels [1].

It is important to note that dietary supplements like St. John's Wort are not regulated by the Food and Drug Administration (FDA) in the same way that prescription medications are [2]. Therefore, the safety and effectiveness of St. John's Wort and other dietary supplements have not been thoroughly studied [2].

If you are taking Lipitor or any other prescription medication, it is important to talk to your healthcare provider before starting any new dietary supplements or medications [1]. Your healthcare provider can help you weigh the potential risks and benefits of taking Lipitor and St. John's Wort together [1].

Sources:

1. Drugs.com. (2021). Simvastatin and St. John's Wort Interaction. Retrieved from <https://www.drugs.com/drug-interactions/simvastatin-and-st-john-s-wort-813-0-1111-0.html>
2. DrugPatentWatch.com. (2021). St. John's Wort. Retrieved from <https://www.drugpatentwatch.com/drugs/st-john-s-wort>