Advil is a brand name for ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, reduce fever, and reduce inflammation. According to Drug Patent Watch [1], Advil was first approved by the US Food and Drug Administration (FDA) in 1984 and is available over-the-counter (OTC) in various formulations, including tablets, capsules, and liquids.

Ibuprofen, the active ingredient in Advil, can be used long-term, but it is important to follow the recommended dosage and consult with a healthcare provider if you have any concerns. According to the Australian Drug Foundation [2], ibuprofen is generally safe when used as directed, but long-term use can increase the risk of side effects such as stomach ulcers, gastrointestinal bleeding, and kidney damage.

A study published in the US National Library of Medicine [3] found that long-term use of ibuprofen was associated with an increased risk of cardiovascular events, such as heart attack and stroke, particularly in people with pre-existing cardiovascular disease. The study also noted that the risk appeared to be dose-dependent, meaning that higher doses of ibuprofen were associated with a higher risk of cardiovascular events.

In summary, Advil (ibuprofen) can be used long-term, but it is important to follow the recommended dosage and consult with a healthcare provider if you have any concerns. Long-term use can increase the risk of side effects such as stomach ulcers, gastrointestinal bleeding, kidney damage, and cardiovascular events, particularly in people with pre-existing cardiovascular disease. It is important to weigh the benefits of using Advil for pain relief against the potential risks and to consider alternative treatments if necessary.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://adf.org.au/drug-facts/ibuprofen/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158445/