Lipitor is a medication used to lower cholesterol levels, and NSAIDs are non-steroidal anti-inflammatory drugs used to reduce pain and inflammation. Taking these two medications together can increase the risk of side effects. According to Drug Patent Watch [1], there are no known drug interactions between Lipitor and NSAIDs. However, it is important to note that the absence of a known interaction does not mean that one does not exist.

One medication that has been found to interact with Lipitor is Paxlovid, which is a combination of ritonavir-boosted nirmatrelvir. According to the NIH COVID-19 Treatment Guidelines [2], taking Paxlovid with Lipitor can increase the levels of Lipitor in the body, leading to an increased risk of side effects. Therefore, it is recommended to monitor patients closely for adverse reactions if they are taking both medications.

A study published in the National Center for Biotechnology Information [3] found that taking NSAIDs with statins, such as Lipitor, can increase the risk of muscle damage and kidney problems. Therefore, it is recommended to avoid taking NSAIDs with Lipitor unless it is absolutely necessary. If NSAIDs are required, it is recommended to use the lowest effective dose for the shortest duration possible.

In conclusion, there are no known drug interactions between Lipitor and NSAIDs, but taking Paxlovid with Lipitor can increase the risk of side effects. It is recommended to avoid taking NSAIDs with Lipitor unless it is absolutely necessary and to use the lowest effective dose for the shortest duration possible. Patients should always consult with their healthcare provider before taking any new medications or changing their medication regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422108/