Vascepa (icosapent ethyl) is a prescription medication used to lower triglyceride levels in adults with severe hypertriglyceridemia. It is an omega-3 fatty acid that works by reducing the production of triglycerides in the liver [1]. Antidepressants, on the other hand, are a group of drugs used to treat depression and other mental health conditions by altering the levels of certain chemicals in the brain [2].

There is no evidence of any harmful interaction between Vascepa and antidepressants [3]. However, it is important to note that some antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), can increase the risk of bleeding, and combining them with Vascepa, which also has anticoagulant properties, may further increase this risk [2]. Therefore, it is recommended that patients taking both Vascepa and antidepressants should be monitored closely for signs of bleeding, such as unusual bruising or bleeding gums [3].

It is also important to inform your doctor of all medications you are taking, including over-the-counter drugs and supplements, as some of them may interact with Vascepa and antidepressants [2]. Your doctor can help you determine the best treatment plan for your condition while minimizing the risk of adverse effects.

In conclusion, while there is no evidence of any harmful interaction between Vascepa and antidepressants, patients taking both medications should be closely monitored for signs of bleeding. It is also important to inform your doctor of all medications you are taking to avoid any potential interactions [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.everydayhealth.com/drugs/vascepa
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063202/