Tigecycline, a broad-spectrum antibiotic, has unique properties that make it a valuable option in certain situations. It is often used for complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia. However, in cases where tigecycline cannot be used or is not available, alternative antibiotics may be considered based on the specific infection being treated and the patient's individual circumstances. Consulting with a healthcare provider or infectious disease specialist is crucial to determine the most appropriate substitute antibiotic based on the particular clinical scenario.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707899/
[3] https://pubmed.ncbi.nlm.nih.gov/16790575/