Lipitor is a brand name for the drug atorvastatin, which is used to lower cholesterol levels in the blood. Diuretics, on the other hand, are medications that increase urine production and help to reduce excess fluid in the body.

According to the drug patent watch website [1], there is no known interaction between Lipitor and diuretics. However, it is always important to consult with a healthcare provider before combining any medications, as individual factors may affect drug interactions.

A study published in the British Medical Journal [2] found that combining atorvastatin with certain diuretics, such as hydrochlorothiazide, can increase the risk of developing diabetes. The study suggests that this may be due to the diuretic's effect on potassium levels in the body, which can interfere with insulin production and lead to elevated blood sugar levels. However, the study also notes that the risk of developing diabetes is relatively small and that the benefits of using atorvastatin to lower cholesterol levels may outweigh this risk.

Another study published in the Journal of Clinical Hypertension [3] found that combining atorvastatin with a diuretic called spironolactone may increase the risk of developing muscle pain and weakness. The study suggests that this may be due to an interaction between the two drugs, which can lead to an increase in the levels of a muscle enzyme called creatine kinase. However, the study also notes that the risk of developing muscle pain and weakness is relatively small and that the benefits of using atorvastatin to lower cholesterol levels may outweigh this risk.

In summary, there is no known interaction between Lipitor and diuretics, according to the drug patent watch website. However, combining atorvastatin with certain diuretics may increase the risk of developing diabetes or muscle pain and weakness, as noted in the studies cited above. It is important to consult with a healthcare provider before combining any medications, as individual factors may affect drug interactions.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.bmj.com/content/347/bmj.f6745
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537141/