Lemonade, like grapefruit juice, contains compounds that can interfere with the metabolism of certain medications, including statins like Lipitor. These compounds inhibit an enzyme in the intestines that is responsible for breaking down Lipitor, leading to higher levels of the drug in the bloodstream. This can potentially increase the risk of side effects associated with Lipitor, such as muscle pain or liver damage. It is advisable to consult with a healthcare provider before consuming lemonade or other citrus juices while taking Lipitor to avoid any potential interactions or adverse effects[2].

Sources:
[2] https://www.healthline.com/health/high-cholesterol/grapefruit-and-statins