Lipitor is a medication that is primarily used to lower cholesterol levels in the body [1]. According to the sources provided, there is no direct evidence that suggests that Lipitor can worsen antidepressant side effects. However, some of the side effects of Lipitor include insomnia and nightmares [2].

It is possible that these side effects may exacerbate pre-existing depression or anxiety symptoms in some individuals. Additionally, a study published in the Journal of Clinical Psychiatry found that nightmares and sleep disturbances can be a potential side effect of some antidepressant medications [3].

Therefore, it is important for individuals taking Lipitor and antidepressants to monitor their symptoms closely and report any concerns to their healthcare provider. It is also important to note that each individual may respond differently to medications, and what works for one person may not work for another.

In conclusion, while there is no direct evidence that Lipitor can worsen antidepressant side effects, the medication may cause insomnia and nightmares which could exacerbate pre-existing depression or anxiety symptoms. It is important for individuals to monitor their symptoms closely and report any concerns to their healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/drugs/side-effects/medications-that-cause-nightmares-and-disturbing-dreams
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652357/