Based on the information available, it is possible for non-statin drugs to have similar effects on the liver as Lipitor (atorvastatin), a type of statin drug commonly used to lower cholesterol levels. However, the specific liver effects and the mechanisms by which non-statin drugs may replicate these effects can vary significantly.

Statin drugs, including Lipitor, have been associated with a range of liver-related side effects, such as elevated liver enzymes and, in rare cases, liver damage or failure [1]. While non-statin drugs are not typically used to lower cholesterol levels, some of them may still impact liver function.

For instance, certain non-statin cholesterol-lowering drugs, such as bile acid sequestrants and fibrates, have been linked to liver enzyme elevations and other liver-related side effects [2]. However, these effects are generally less common and less severe compared to those associated with statin drugs.

Additionally, some non-statin drugs used for other medical conditions may also affect liver function. For example, certain antibiotics, antidepressants, and non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with liver enzyme elevations and liver injury [3].

It is essential to note that individual responses to medications can vary significantly, and not all patients will experience liver-related side effects from either statin or non-statin drugs. Furthermore, the risk-benefit profile of each medication should be carefully considered in the context of a patient's overall health status and treatment goals.

In summary, while non-statin drugs may have liver effects similar to Lipitor, these effects are typically less common and less severe. Patients should consult with their healthcare providers to discuss the potential risks and benefits of any medication before starting or changing a treatment regimen.

Sources:

1. "Lipitor (Atorvastatin)". Drugs.com. <https://www.drugs.com/lipitor.html>
2. "Nonstatin Therapies for Lipid Disorders". American Family Physician. <https://www.aafp.org/afp/2011/0201/p313.html>
3. "Drug-Induced Liver Injury". National Library of Medicine. <https://livertox.nih.gov/DILI.cfm>
4. "Atorvastatin (Lipitor)". DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/atorvastatin>