Mixing Lipitor, a cholesterol-lowering drug, with certain blood pressure (BP) medications can lead to increased risks of side effects and health complications.

Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood, thereby reducing the risk of heart attack and stroke [1]. When combined with certain BP drugs, specifically calcium channel blockers, the risk of muscle damage (myopathy) and kidney damage (renal failure) may increase [2][3].

Calcium channel blockers, a type of BP drug, work by relaxing the muscles of the blood vessels, causing them to widen and decrease blood pressure [3]. When combined with Lipitor, the risk of these side effects increases due to the interaction between the two medications [2].

Additionally, consuming grapefruit juice while taking Lipitor can also increase the risk of side effects [2]. Grapefruit juice can increase the amount of Lipitor in the bloodstream, which can lead to an increased risk of muscle and kidney damage [2].

It is important to consult with a healthcare provider before starting or stopping any medication, and to discuss any potential interactions with other medications or foods [3]. Patients should provide their healthcare provider with a complete list of all medications, supplements, and foods they consume to ensure safe and effective treatment [3].

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
[2] <https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix>
[3] <https://www.heart.org/en/health-topics/consumer-healthcare/medication-information/medication-interactions-food-supplements-and-other-drugs>