Acetaminophen is a widely used pain reliever and fever reducer that is available over-the-counter (OTC) and by prescription. It is considered safe when taken as directed, but there are some risks associated with its use.

One of the main risks of acetaminophen is liver damage, especially when taken in large doses or over a long period of time. According to the FDA, taking more than the recommended dose of acetaminophen can cause liver damage, and in severe cases, liver failure, which can be fatal [2]. The risk of liver damage is increased in people who drink alcohol regularly, have liver disease, or take other medications that can affect the liver [1].

Another risk of acetaminophen is the potential for overdose, which can also lead to liver damage or failure. According to the FDA, an overdose of acetaminophen can occur when someone takes more than the recommended dose at one time, takes more than one acetaminophen-containing product at the same time, or takes acetaminophen with alcohol [2].

Acetaminophen can also cause allergic reactions in some people, although this is rare. Symptoms of an allergic reaction can include rash, hives, itching, swelling, difficulty breathing, and dizziness [3].

In addition, acetaminophen can interact with other medications, including blood thinners, certain antibiotics, and some medications used to treat high blood pressure, which can increase the risk of side effects [1].

Overall, acetaminophen is considered safe when taken as directed, but it is important to be aware of the risks associated with its use. To reduce the risk of liver damage and overdose, it is important to follow the recommended dosage and avoid taking more than one acetaminophen-containing product at the same time. People with liver disease or who drink alcohol regularly should talk to their doctor before taking acetaminophen. If you experience any symptoms of an allergic reaction or other side effects, stop taking acetaminophen and seek medical attention.

Sources:
[1] https://www.health.harvard.edu/pain/acetaminophen-safety-be-cautious-but-not-afraid
[2] https://medlineplus.gov/druginfo/meds/a681004.html
[3] https://www.drugpatentwatch.com/p/tradename/ACETAMINOPHEN