Methotrexate is a medication used to treat various conditions such as cancer, autoimmune diseases, and ectopic pregnancy. As with any medication, there are potential risks and side effects that should be considered, especially when it comes to elderly patients.

According to DrugPatentWatch [1], Methotrexate has been on the market since 1953 and has been used to treat a variety of conditions, including rheumatoid arthritis. The patent for Methotrexate has expired, which means that it is available in generic form and is less expensive than the brand-name version.

A study published in the British Medical Journal [2] found that Methotrexate is generally safe for elderly patients with rheumatoid arthritis, but it is important to monitor for potential side effects such as liver toxicity, bone marrow suppression, and infections. The study also noted that elderly patients may be more susceptible to side effects due to age-related changes in the body.

Another study published in the Journal of Rheumatology [3] found that low-dose Methotrexate is effective and safe for elderly patients with rheumatoid arthritis, with a low incidence of side effects. The study recommended that elderly patients be monitored closely for potential side effects and that the dose be adjusted if necessary.

In conclusion, Methotrexate can be a safe and effective medication for elderly patients, especially for those with rheumatoid arthritis. However, it is important to monitor for potential side effects and adjust the dose if necessary. As with any medication, it is important to consult with a healthcare professional before starting Methotrexate.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1741826/
[3] https://pubmed.ncbi.nlm.nih.gov/8972245/