Advil is a nonsteroidal anti-inflammatory drug (NSAID) that contains ibuprofen and is commonly used to treat pain, inflammation, and fever [3]. According to the official Advil website, the medication can be taken with or without food [3]. However, it is important to note that certain foods can affect how the body absorbs and processes drugs. For example, grapefruit juice can interfere with the way certain drugs are metabolized in the liver, which can increase the risk of side effects [2]. Fortunately, there is no evidence to suggest that Advil interacts with grapefruit juice [2].

It is worth noting that while Advil can be taken with food, it is generally recommended to take it with a full glass of water to help prevent stomach upset [3]. Additionally, it is important to follow the dosing instructions provided by a healthcare professional or the medication label, as taking too much Advil can increase the risk of side effects such as stomach bleeding, kidney damage, and heart attack [1].

In summary, Advil can be taken with or without food, and there is no evidence to suggest that it interacts with grapefruit juice. However, it is important to take the medication with a full glass of water to help prevent stomach upset and to follow the dosing instructions provided by a healthcare professional or the medication label to avoid potential side effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix
[3] https://www.advil.com/faqs-en/advil-pain/