Acyclovir, a medication commonly used to treat viral infections such as herpes, can indeed interact with other medications or substances. It is crucial to be aware of these potential interactions to avoid adverse effects or reduced effectiveness of the treatment. Some medications that may interact with acyclovir include probenecid, nephrotoxic drugs, and certain chemotherapy medications. Probenecid can increase the concentration of acyclovir in the body, potentially leading to side effects. Nephrotoxic drugs, like aminoglycoside antibiotics or cisplatin, may increase the risk of kidney damage when used with acyclovir. Chemotherapy drugs, particularly those that affect the kidneys, can also have increased toxicity when combined with acyclovir. It is advisable to consult a healthcare provider or pharmacist before taking acyclovir to ensure safe and effective treatment, especially if you are already taking other medications or have underlying health conditions. [2][3][4]

Sources:
[2] www.mayoclinic.org/drugs-supplements/acyclovir-oral-route-intravenous-route/before-using/drg-20068393
[3] www.drugs.com/drug-interactions/acyclovir.html