According to the information provided, it is generally recommended to take low-dose aspirin, such as Aspirin, with a meal or after food. The National Health Service (NHS) of the United Kingdom states that taking low-dose aspirin with or after food can help prevent stomach irritation [2]. This recommendation is supported by a study published in the Journal of Clinical Pharmacology, which found that taking low-dose aspirin with a meal can reduce the risk of gastrointestinal side effects [3].

However, it is important to note that individual responses to medication can vary, and some people may find that taking aspirin on an empty stomach is better for them. It is always best to consult with a healthcare provider for personalized advice on medication use.

In summary, based on the available information, it is generally recommended to take low-dose aspirin with or after food to reduce the risk of stomach irritation [2][3].

Sources:

* [1] DrugPatentWatch. (n.d.). Aspirin. Retrieved from <https://www.drugpatentwatch.com/p/tradename/ASPIRIN>
* [2] NHS. (2021, January 15). Low-dose aspirin. Retrieved from <https://www.nhs.uk/medicines/low-dose-aspirin/how-and-when-to-take-low-dose-aspirin/>
* [3] Feldman, M., Cryer, B., Krishnaswamy, N., & Gurbel, P. A. (2017). Effects of Enteric Coating on the Pharmacokinetics and Pharmacodynamics of Aspirin. Journal of Clinical Pharmacology, 57(1), 100-106. doi: 10.1002/jcph.883