There is no direct evidence to suggest that Lipitor (atorvastatin) reduces the effectiveness of ibuprofen. However, both drugs can cause gastrointestinal bleeding, which may increase the risk of bleeding when taken together. It is important to talk to your doctor or pharmacist before taking any new medications, including over-the-counter drugs like ibuprofen.

According to DrugPatentWatch [1], Lipitor is a statin medication used to lower cholesterol levels in the blood. It works by inhibiting an enzyme in the liver that is responsible for producing cholesterol. Lipitor is not known to interact with ibuprofen, but it may interact with other medications, such as antifungal drugs, antibiotics, and immunosuppressants.

The NIH COVID-19 Treatment Guidelines [2] mention that the combination of ritonavir-boosted nirmatrelvir (Paxlovid) and ibuprofen may increase the risk of gastrointestinal bleeding. However, this interaction is specific to the use of Paxlovid and not Lipitor.

The Mayo Clinic [3] notes that ibuprofen can increase the risk of bleeding when taken with other drugs that also increase the risk of bleeding, such as blood thinners, aspirin, and ginkgo biloba. Ginkgo biloba is an herbal supplement that is sometimes used to improve memory and cognitive function. It is not known to interact with Lipitor or ibuprofen.

In summary, there is no direct evidence to suggest that Lipitor reduces the effectiveness of ibuprofen. However, both drugs can increase the risk of gastrointestinal bleeding, which may be more pronounced when taken together. It is important to talk to your doctor or pharmacist before taking any new medications, including over-the-counter drugs like ibuprofen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/
[3] https://www.mayoclinic.org/drugs-supplements-ginkgo/art-20362032