Combining Advil and antidepressants may have potential side effects. Advil is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce inflammation and pain, while antidepressants are used to treat depression, anxiety, and other mental health disorders.

According to Drug Patent Watch [1], Advil contains ibuprofen, which can interact with certain antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). This interaction can increase the risk of gastrointestinal bleeding and may also affect the effectiveness of the antidepressant.

A study published in the National Center for Biotechnology Information [2] also suggests that combining Advil with certain antidepressants can increase the risk of bleeding. The study recommends that patients should be monitored for signs of bleeding if they are taking both medications.

The National Health Service [3] also advises caution when taking Advil and antidepressants together. They recommend that patients should consult their doctor or pharmacist before taking any new medication, including over-the-counter drugs like Advil. Patients should also inform their doctor if they are taking antidepressants before taking Advil.

In conclusion, combining Advil and antidepressants can increase the risk of bleeding and affect the effectiveness of the antidepressant. Patients should consult their doctor or pharmacist before taking any new medication and should be monitored for signs of bleeding if they are taking both medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884264/
[3] https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/