Lipitor is a brand name for the drug atorvastatin, which is a type of medication used to lower cholesterol levels in the blood. According to the Drug Patent Watch [1], Lipitor is a statin that works by inhibiting an enzyme called HMG-CoA reductase, which is involved in the production of cholesterol in the liver. However, taking Lipitor with high-fat meals can affect its effectiveness.

A study published in the National Center for Biotechnology Information [3] states that taking atorvastatin with a high-fat meal reduces its absorption, which can decrease its effectiveness in lowering cholesterol levels. The study found that taking atorvastatin with a high-fat meal decreased its maximum concentration by 49% and delayed its absorption by 4 hours.

The keto diet is a high-fat, low-carbohydrate diet that has gained popularity in recent years for weight loss and other health benefits. However, according to a Penn Medicine News Blog [2], the keto diet can also affect the effectiveness of medications like Lipitor. The blog post quotes a cardiologist who says that the keto diet can increase the risk of side effects from statins like Lipitor, as well as decrease their effectiveness.

In conclusion, taking Lipitor with high-fat meals can affect its effectiveness in lowering cholesterol levels. It is important to follow the prescribed dosing instructions and to talk to a healthcare provider about any concerns regarding diet and medication interactions.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.pennmedicine.org/news/news-blog/2019/april/a-cardiologists-take-on-the-keto-diet
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766553/