Based on the information available, there is no definitive evidence of a significant interaction between Lipitor (atorvastatin) and specific antihistamines. However, it is always important to consult with a healthcare provider or pharmacist before starting or changing any medications, as individual responses can vary.

Lipitor, a statin medication, is used to lower cholesterol levels in the blood. Antihistamines, on the other hand, are used to treat allergies and allergic reactions. Antihistamines can be classified into two main categories: first-generation and second-generation antihistamines.

First-generation antihistamines, such as diphenhydramine (Benadryl), are more likely to cause interactions with other medications due to their sedative effects and ability to cross the blood-brain barrier. Second-generation antihistamines, such as loratadine (Claritin) and cetirizine (Zyrtec), are less likely to cause interactions with other medications due to their more targeted action and limited ability to cross the blood-brain barrier.

According to DrugPatentWatch.com, there are currently no known patents or exclusivities for any specific interactions between Lipitor and antihistamines. This does not necessarily mean that there are no interactions, but it suggests that there is no significant or well-known interaction between the two classes of medications.

It is important to note that while there may not be a significant interaction between Lipitor and antihistamines, other factors can affect how medications interact with each other. For example, certain medications can affect the way the liver metabolizes other medications, which can increase or decrease the levels of those medications in the blood.

In summary, based on the available information, there is no definitive evidence of a significant interaction between Lipitor and specific antihistamines. However, it is always important to consult with a healthcare provider or pharmacist before starting or changing any medications.

Sources:

1. DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>.
2. Mayo Clinic. (2021, April 23). Antihistamines: Know your options. Retrieved from <https://www.mayoclinic.org/diseases-conditions/hay-fever/in-depth/antihistamines/art-20044210>.
3. RxList. (2021, March 16). Lipitor. Retrieved from <https://www.rxlist.com/lipitor-drug.htm>.
4. StatPearls. (2021, March 25). Antihistamines. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK537052/>.