There is no definitive evidence to suggest that Lipitor, a medication used to treat high cholesterol, becomes less effective when taken with iron-rich plant foods. However, it's important to note that certain substances can interact with medications, potentially affecting their efficacy or causing side effects.

Lipitor, also known as atorvastatin, is a statin drug that works by reducing the amount of cholesterol your body absorbs, helping to lower your levels of "bad" cholesterol and triglycerides, and increase "good" cholesterol [1].

Iron-rich plant foods, such as spinach, broccoli, and lentils, are nutritious and beneficial for overall health. They are rich in dietary fiber, antioxidants, and essential vitamins and minerals [2].

When it comes to drug interactions, the National Library of Medicine's Drug Interactions Checker does not list iron as a substance that interacts with Lipitor [3]. However, it is always recommended to consult with a healthcare provider or pharmacist for personalized advice, as individual responses to medications and dietary interactions can vary.

In conclusion, based on the available information, there is no evidence to suggest that Lipitor is less effective when taken with iron-rich plant foods. However, it is always important to consult with a healthcare provider or pharmacist for personalized advice regarding medication and dietary interactions.

Sources:
[1] Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20063091>
[2] Harvard T.H. Chan School of Public Health. (n.d.). Plant-Based Diets. Retrieved from <https://www.hsph.harvard.edu/nutritionsource/healthy-weight/diet-reviews/plant-based/>
[3] U.S. National Library of Medicine. (n.d.). Drug Interactions Checker. Retrieved from <https://medlineplus.gov/druginfo/meds/a601242.html>
[4] DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>