Lipitor is a prescription medication used to lower cholesterol levels in the blood, while painkillers are medications used to relieve pain. Combining Lipitor with painkillers can potentially lead to side effects.

According to Drug Patent Watch [1], Lipitor can interact with certain painkillers, such as nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, ibuprofen, and naproxen. These painkillers can reduce the effectiveness of Lipitor and increase the risk of muscle damage, a known side effect of the medication.

In addition, a study published in the US National Library of Medicine [2] found that combining Lipitor with opioid painkillers, such as codeine and morphine, can increase the risk of muscle pain and weakness, a known side effect of both medications.

Moreover, the National Institute on Alcohol Abuse and Alcoholism [3] warns against combining alcohol with Lipitor or painkillers, as it can increase the risk of liver damage and other harmful side effects.

It is important to note that not all painkillers interact with Lipitor in the same way, and the severity of the side effects can vary depending on the individual and the specific medications being taken. Therefore, it is crucial to consult with a healthcare provider before combining Lipitor with any painkillers or other medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
[3] https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines