Lipitor is a medication that is commonly used to treat high cholesterol levels in the body. The active ingredient in Lipitor is atorvastatin, which works by reducing the production of cholesterol in the liver [1].

According to a study published in the Journal of Clinical Lipidology, a high-fat diet can significantly reduce the effectiveness of atorvastatin [2]. The study found that individuals who consumed a high-fat diet had lower levels of atorvastatin in their bloodstream compared to those who followed a low-fat diet. This suggests that a high-fat diet can interfere with the absorption and metabolism of atorvastatin, potentially reducing its effectiveness in lowering cholesterol levels.

Another study published in the Journal of Cardiovascular Pharmacology found that taking atorvastatin with a high-fat meal can increase the absorption of the drug by up to 30% [3]. However, the study also noted that this increase in absorption did not result in a significant increase in the effectiveness of the drug in lowering cholesterol levels.

In conclusion, while taking Lipitor with a high-fat diet may increase the absorption of the drug, it may also reduce its effectiveness in lowering cholesterol levels. Therefore, it is recommended to follow a low-fat diet while taking Lipitor to ensure optimal effectiveness of the medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766553/
[3] https://pubmed.ncbi.nlm.nih.gov/21269482/