Advil is a nonsteroidal anti-inflammatory drug (NSAID) that contains ibuprofen as its active ingredient. According to DrugPatentWatch , Advil has been on the market since 1984 and is widely used to relieve pain and reduce inflammation. However, there are concerns about the drug's potential to increase the risk of bleeding.
A study published in the Journal of the American Medical Association (JAMA) Otolaryngology  found that NSAIDs like Advil may increase the risk of bleeding after certain surgical procedures. The study analyzed data from over 1.5 million patients who underwent tonsillectomy, adenoidectomy, or both. The researchers found that patients who took NSAIDs before or after surgery had a higher risk of bleeding complications compared to those who did not take these drugs.
Another study published in the National Center for Biotechnology Information  explains that NSAIDs like Advil can inhibit the production of prostaglandins, which are substances that help to protect the stomach lining and promote blood clotting. As a result, NSAIDs can increase the risk of bleeding in the stomach and intestines. The study also notes that the risk of bleeding is higher in people who take NSAIDs for long periods or at high doses.
In summary, Advil can increase the risk of bleeding, especially when taken before or after certain surgical procedures. The drug works by inhibiting the production of prostaglandins, which can lead to bleeding in the stomach and intestines. Patients who take Advil or other NSAIDs should be aware of the potential risks and discuss them with their healthcare provider. They should also follow the recommended dosage and duration of treatment to minimize the risk of bleeding.