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How does lipitor affect liver enzymes?



Lipitor is a brand name for the drug atorvastatin, which is a medication used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins. According to DrugPatentWatch [1], Lipitor works by inhibiting the enzyme HMG-CoA reductase, which is responsible for producing cholesterol in the liver. By inhibiting this enzyme, Lipitor reduces the amount of cholesterol that the liver produces and releases into the bloodstream.

However, as with any medication, Lipitor can have side effects. One of the potential side effects is an increase in liver enzymes, which can be a sign of liver damage. MedicalNewsToday [2] explains that an increase in liver enzymes can be detected through a blood test. The article also notes that in rare cases, Lipitor can cause liver damage, which can lead to liver failure.

A study published in the Journal of Clinical Lipidology [3] investigated the effect of atorvastatin on liver enzymes in patients with hyperlipidemia. The study found that atorvastatin was associated with a small increase in liver enzymes, but this increase was not considered clinically significant. The study also noted that the increase in liver enzymes was reversible and returned to normal levels once the medication was discontinued.

In conclusion, Lipitor works by inhibiting the enzyme responsible for producing cholesterol in the liver. While Lipitor can cause an increase in liver enzymes, this increase is generally not considered clinically significant and is reversible. However, in rare cases, Lipitor can cause liver damage, which can lead to liver failure. If you are taking Lipitor and experience any symptoms of liver damage, such as yellowing of the skin or eyes, dark urine, or abdominal pain, you should seek medical attention immediately.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.medicalnewstoday.com/articles/drugs-lipitor-side-effects
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070374/



Follow-up:   Are high liver enzymes common with Lipitor? Can Lipitor cause liver damage? How often should liver function be monitored on Lipitor?





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