Based on the available information, it is recommended to consult with a healthcare professional before combining Advil with antidepressants. Advil is a brand name for ibuprofen, an non-steroidal anti-inflammatory drug (NSAID) [1][2]. Ibuprofen can interact with certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) [3].

The interaction between ibuprofen and antidepressants can increase the risk of stomach ulcers, bleeding, and kidney problems [3]. Additionally, there is a potential risk of a serious condition called serotonin syndrome, which occurs when the body has too much serotonin, a chemical produced by the brain [3]. Symptoms of serotonin syndrome can include agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, heavy sweating, diarrhea, and fever [3].

It is important to note that not all antidepressants will interact with ibuprofen, and the risk of interaction may depend on the dose and duration of use [3]. Therefore, it is crucial to consult with a healthcare professional before combining Advil with antidepressants to ensure safe and effective treatment [2].

Sources:

[1] DrugPatentWatch. (n.d.). Advil. Retrieved from <https://www.drugpatentwatch.com/p/tradename/ADVIL>

[2] NHS. (2021, April 21). Ibuprofen for adults: Taking ibuprofen with other medicines and herbal supplements. Retrieved from <https://www.nhs.uk/medicines/ibuprofen-for-adults/taking-ibuprofen-with-other-medicines-and-herbal-supplements/>

[3] Zhang, Y., & Henry, D. (2021). Drug-Drug Interactions Between Antidepressants and Nonsteroidal Anti-Inflammatory Drugs. International journal of molecular sciences, 22(5), 2563. <https://doi.org/10.3390/ijms22052563>