There is no known adverse effect of combining Lipitor and guacamole. Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood [1]. It works by inhibiting an enzyme in the liver that produces cholesterol. On the other hand, guacamole is a dip made from mashed avocado, onion, tomato, and other ingredients, and it is generally considered a healthy food choice [2].

However, it is important to note that some foods can interact with Lipitor and affect its effectiveness or increase the risk of side effects. For example, grapefruit and grapefruit juice can increase the level of Lipitor in the blood, leading to a higher risk of side effects [2]. Therefore, it is recommended to avoid grapefruit or grapefruit juice while taking Lipitor.

Overall, there is no evidence to suggest that guacamole has any adverse effects when combined with Lipitor. However, if you have any concerns about drug and food interactions, it is always best to consult with your healthcare provider.

Sources:
[1] DrugPatentWatch. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Stat News. (2016, November 3). How medications can interact with your favorite foods. Retrieved from https://www.statnews.com/2016/11/03/medications-food-drug-interactions/
[3] PubMed. (2021). Atorvastatin. Retrieved from https://pubmed.ncbi.nlm.nih.gov/34332788/