Azacitidine is a medication used to treat certain types of blood cancers, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). While it can be an effective treatment option, it is important to be aware of potential side effects.

According to the sources provided, here are some common side effects associated with azacitidine:

1. Nausea and vomiting: Azacitidine can cause gastrointestinal symptoms such as nausea and vomiting. It is recommended to take anti-nausea medications as prescribed by the healthcare provider to manage these symptoms.

2. Injection site reactions: Azacitidine is administered through injections, and it can cause pain, redness, or swelling at the injection site. Inform your healthcare provider if you experience any discomfort at the injection site.

3. Fatigue: Azacitidine may cause fatigue or tiredness. It is important to get enough rest and conserve energy while undergoing treatment.

4. Low blood cell counts: Azacitidine can affect the production of blood cells in the bone marrow, leading to low levels of red blood cells, white blood cells, and platelets. This can result in anemia, increased risk of infections, and bleeding. Regular blood tests will be conducted to monitor blood cell counts, and your healthcare provider will take appropriate measures if any abnormalities are detected.

5. Diarrhea or constipation: Azacitidine may cause gastrointestinal disturbances, including diarrhea or constipation. It is important to maintain good hydration and follow a balanced diet to manage these symptoms. Inform your healthcare provider if these symptoms persist or worsen.

6. Fever: Some patients may experience fever during treatment with azacitidine. It is important to monitor your body temperature and inform your healthcare provider if you develop a fever.

7. Muscle or joint pain: Azacitidine may cause muscle or joint pain. Inform your healthcare provider if you experience any discomfort in your muscles or joints.

8. Rash or skin reactions: Azacitidine can cause skin reactions such as rash or itching. Inform your healthcare provider if you develop any skin changes or allergic reactions.

It is important to note that not all patients will experience these side effects, and the severity can vary from person to person. Your healthcare provider will monitor your progress and manage any side effects that may occur.

In summary, common side effects of azacitidine include nausea, vomiting, injection site reactions, fatigue, low blood cell counts, diarrhea or constipation, fever, muscle or joint pain, and rash or skin reactions. It is important to discuss any concerns or side effects with your healthcare provider to ensure proper management.

Sources:
[1] Drug Patent Watch. Azacitidine Side Effects. Retrieved from: https://www.drugpatentwatch.com/p/tradename/AZACITIDINE
[2] Mayo Clinic. Azacitidine (Injection Route) - Side Effects. Retrieved from: https://www.mayoclinic.org/drugs-supplements/azacitidine-injection-route/side-effects/drg-20062061
[3] MedlinePlus. Azacitidine Injection. Retrieved from: https://medlineplus.gov/druginfo/meds/a607068.html