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Are there patient specific factors affecting tigecycline dosage?

See the DrugPatentWatch profile for tigecycline

Yes, there are patient-specific factors that can affect Tigecycline dosage. Tigecycline is an antibiotic used to treat various bacterial infections, and its dosage can be influenced by several patient-specific factors.

One such factor is renal function. Tigecycline is primarily excreted by the biliary system, with less than 15% of the dose eliminated renally [1]. However, in patients with severe renal impairment, including those on dialysis, the dosage of Tigecycline should be reduced [1].

Another factor that can affect Tigecycline dosage is hepatic function. Tigecycline is metabolized in the liver, and its clearance can be reduced in patients with hepatic impairment [1]. Therefore, a reduced dosage may be necessary for patients with severe hepatic impairment [1].

Additionally, Tigecycline has a higher volume of distribution, which can lead to a lower serum concentration in obese patients [2]. Therefore, a higher dosage may be required for obese patients to achieve the desired therapeutic concentration [2].

It is important to note that Tigecycline has a black box warning for increased mortality in patients with severe infections [1]. Therefore, it should be used judiciously and only when other antibiotics are not suitable [1].

In summary, renal and hepatic function, as well as body weight, can affect Tigecycline dosage. Healthcare providers should consider these patient-specific factors when prescribing Tigecycline.

Sources:
[1] Tigecycline prescribing information. U.S. Food and Drug Administration. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s013lbl.pdf>.
[2] Tigecycline dosing. DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/tigecycline>.


Other Questions About Tigecycline :  Why is off patent tigecycline still prescribed? How do stewardship programs promote responsible tigecycline use? Are there any drug interactions to be cautious of with tigecycline?





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