Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood, while monoamine oxidase inhibitors (MAOIs) are a type of antidepressant medication that works by increasing the levels of certain neurotransmitters in the brain.

There is limited information available on how Lipitor affects MAOI effectiveness, and the sources do not provide a direct answer to this question. However, there are some potential interactions and precautions to be aware of when taking these medications together.

According to DrugPatentWatch [1], there are no known drug interactions between Lipitor and MAOIs. However, this does not necessarily mean that there are no potential interactions, as drug interactions can be complex and vary depending on the individual.

The Mayo Clinic [2] advises that MAOIs can interact with a wide range of medications, including some over-the-counter drugs and herbal supplements, and can cause serious side effects such as high blood pressure and serotonin syndrome. Therefore, it is important to inform your healthcare provider of all medications and supplements you are taking before starting an MAOI.

A study published in the Journal of Clinical Psychopharmacology [3] found that atorvastatin (the active ingredient in Lipitor) did not have a significant effect on the metabolism of the MAOI phenelzine in healthy volunteers. However, the study authors note that further research is needed to fully understand the potential interactions between atorvastatin and MAOIs.

In summary, while there are no known drug interactions between Lipitor and MAOIs, it is important to inform your healthcare provider of all medications and supplements you are taking before starting an MAOI. Further research is needed to fully understand the potential interactions between atorvastatin and MAOIs.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.mayoclinic.org/diseases-conditions/depression/in-depth/maois/art-20043992
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/