Based on the available information, mixing Lipitor and diuretics could potentially lead to increased risks of side effects. According to the American Heart Association's information on medication interactions, food, supplements, and other drugs [2], combining medications can sometimes lead to unexpected side effects. In the case of Lipitor, a statin drug used to treat high cholesterol [1], and diuretics, which are often used to treat high blood pressure and edema [2], there are potential interactions to be aware of.

The National Center for Biotechnology Information's article "Statins and Muscle: Safety Considerations and Risk Group Identification" [3] explains that statins like Lipitor can cause muscle-related side effects, including myalgia (muscle pain) and, in rare cases, rhabdomyolysis (muscle cell breakdown). Diuretics can also cause electrolyte imbalances, including low potassium levels [2].

When combining Lipitor and diuretics, healthcare providers need to monitor patients closely for potential adverse effects. Electrolyte imbalances caused by diuretics may increase the risk of muscle-related side effects from Lipitor [3]. Patients should inform their healthcare providers of all medications, supplements, and over-the-counter drugs they are taking to help prevent potential interactions [2].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.heart.org/en/health-topics/consumer-healthcare/medication-information/medication-interactions-food-supplements-and-other-drugs
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/