According to the sources provided, there are no significant negative interactions between acyclovir and antibiotics. Acyclovir is an antiviral medication used to treat infections caused by the herpes simplex virus and the varicella-zoster virus. The medication works by preventing the virus from multiplying in the body [1].

WebMD notes that acyclovir may interact with other medications, but antibiotics are not listed among them [2]. The Mayo Clinic also lists potential drug interactions with acyclovir, but again, antibiotics are not mentioned [3].

Drug Patent Watch provides a list of patents related to acyclovir, but does not provide any information on potential drug interactions [1].

Overall, it appears that there are no significant negative interactions between acyclovir and antibiotics. However, as with any medication, it is important to discuss all current medications and medical conditions with a healthcare provider before starting acyclovir or any other new medication [2, 3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ACYCLOVIR
[2] https://www.webmd.com/drugs/2/drug-941/acyclovir-oral/details
[3] https://www.mayoclinic.org/drugs-supplements/acyclovir-oral-route-intravenous-route/precautions/drg-20068393?p=1