Advil is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. According to Drug Patent Watch [1], the active ingredient in Advil is ibuprofen. Antidepressants are medications used to treat depression, anxiety, and other mood disorders. The Mayo Clinic [3] states that there are several types of antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs).

A study published in the National Library of Medicine [2] found that the combination of NSAIDs and antidepressants can increase the risk of gastrointestinal bleeding. This is because both types of medications can irritate the lining of the stomach and intestines, leading to ulcers and bleeding. The study suggests that patients who take both NSAIDs and antidepressants should be closely monitored for signs of gastrointestinal bleeding, such as abdominal pain, nausea, vomiting, and dark, tarry stools.

It is important to note that not all antidepressants interact negatively with NSAIDs. According to the Mayo Clinic [3], SSRIs and SNRIs are generally safe to take with NSAIDs, but TCAs and MAOIs can increase the risk of bleeding. It is also important to talk to your doctor before taking any new medications, including over-the-counter pain relievers like Advil. Your doctor can help you weigh the risks and benefits of taking these medications together and monitor you for any potential side effects.

In conclusion, while Advil and antidepressants can be taken together, they can increase the risk of gastrointestinal bleeding in some cases. Patients who take both medications should be closely monitored for signs of bleeding and should talk to their doctor before taking any new medications. It is also important to note that not all antidepressants interact negatively with NSAIDs, and some types of antidepressants are generally safe to take with these medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508078/
[3] https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20044970