Lipitor, also known by its generic name atorvastatin, is a medication commonly prescribed to lower cholesterol levels in patients with high cholesterol or cardiovascular disease. While it is generally recommended to take Lipitor after meals, there are some exceptions to this guideline.

According to the information provided by Drug Patent Watch, the official prescribing information for Lipitor does not specify whether it should be taken with or without food [1]. However, the website GoodRx suggests that taking Lipitor with food can help improve its absorption and reduce the risk of stomach upset [3]. This is because the presence of food in the stomach can slow down the absorption of the medication, leading to a more gradual release into the bloodstream.

On the other hand, Renown Health advises patients taking heart medications, including statins like Lipitor, to avoid consuming grapefruit and grapefruit juice [2]. Grapefruit contains compounds that can interfere with the metabolism of certain medications, including Lipitor. This can lead to higher levels of the medication in the bloodstream, increasing the risk of side effects.

In summary, while it is generally recommended to take Lipitor after meals to improve absorption and reduce the risk of stomach upset, there are exceptions to this guideline. Patients should avoid consuming grapefruit or grapefruit juice while taking Lipitor due to the potential for drug interactions. It is always best to consult with a healthcare professional or pharmacist for specific instructions on when and how to take Lipitor.

Sources:
[1] Drug Patent Watch: Lipitor prescribing information. Retrieved from: https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Renown Health: Foods to Avoid When Taking Heart Medications. Retrieved from: https://www.renown.org/blog/foods-to-avoid-when-taking-heart-medications
[3] GoodRx: Best Time to Take Cholesterol Medication. Retrieved from: https://www.goodrx.com/classes/statins/best-time-take-cholesterol-medication