Lipitor is a medication used to lower cholesterol levels in the blood. The active ingredient in Lipitor is atorvastatin, which belongs to a class of drugs called statins [1]. Statins work by reducing the amount of cholesterol produced by the liver. However, there are potential risks associated with combining Lipitor with citrus fruits, particularly grapefruit.

Grapefruit contains compounds that can interfere with the metabolism of certain drugs, including Lipitor. These compounds inhibit an enzyme in the liver that is responsible for breaking down Lipitor, leading to higher levels of the drug in the bloodstream. This can increase the risk of side effects, such as muscle pain and liver damage [2].

According to GoodRx, the interaction between grapefruit and Lipitor is so significant that it is recommended to avoid grapefruit altogether while taking Lipitor [2]. Healthline also suggests avoiding grapefruit and other citrus fruits, such as Seville oranges and tangelos, while taking Lipitor [3].

In summary, combining Lipitor with citrus fruits, particularly grapefruit, can increase the risk of side effects and should be avoided. It is important to consult with a healthcare provider before making any changes to medication or diet.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin
[3] https://www.healthline.com/health/high-cholesterol/grapefruit-and-statins