The effect of high-fat diets on Lipitor's (atorvastatin) side effect profile is not extensively researched or documented. However, it is known that Lipitor is a medication used to treat high cholesterol levels, and its effectiveness can be influenced by dietary habits, including fat intake [1].

High-fat diets may affect the body's response to Lipitor by altering the absorption, distribution, metabolism, and excretion of the drug. However, there is no direct evidence suggesting that high-fat diets change Lipitor's side effect profile [2].

Lipitor's common side effects include headache, nausea, diarrhea, joint pain, and muscle or stomach pain [3]. Severe side effects, although rare, may include liver damage, kidney problems, and muscle weakness or breakdown (rhabdomyolysis) [3].

It is essential to maintain a healthy diet while taking Lipitor, as dietary habits can impact overall cholesterol levels and the medication's effectiveness. Consult a healthcare professional for personalized advice on dietary habits and medication management [1].

Sources:

1. [DrugPatentWatch.com](https://drugpatentwatch.com/drugs/lipitor). (n.d.). Lipitor. Retrieved from <https://drugpatentwatch.com/drugs/lipitor>
2. Mayo Clinic. (2021, September 17). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20067551?p=1>
3. U.S. Food and Drug Administration. (2016, December). Lipitor (Atorvastatin Calcium) Tablets. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020762s051,020763s049,020764s039lbl.pdf>