Aspirin and Lipitor are two commonly used medications, but when taken together, they can have potential adverse effects. Aspirin, also known as acetylsalicylic acid, is a common over-the-counter pain reliever, while Lipitor (atorvastatin) is a prescription medication used to treat high cholesterol.

One potential adverse effect of combining aspirin and Lipitor is an increased risk of bleeding [1]. Aspirin is a blood thinner, which means it can prevent blood clots from forming. However, this can also increase the risk of bleeding, especially in the stomach and intestines. Lipitor, on the other hand, can increase the levels of a substance in the body called plasminogen activator inhibitor-1 (PAI-1), which can also increase the risk of bleeding [2].

Another potential adverse effect of combining aspirin and Lipitor is an increased risk of muscle damage [1]. Lipitor belongs to a class of drugs called statins, which can sometimes cause muscle pain and damage. Aspirin can increase the levels of statins in the body, which can increase the risk of muscle damage [3].

It is important to note that the risk of these adverse effects is generally low, and the benefits of taking aspirin and Lipitor together may outweigh the risks for some people. However, it is always important to talk to a healthcare provider before starting or stopping any medication, especially if you are taking multiple medications or have a history of bleeding or muscle pain.

In summary, the potential adverse effects of combining aspirin and Lipitor include an increased risk of bleeding and muscle damage. While the risk of these adverse effects is generally low, it is important to talk to a healthcare provider before starting or stopping any medication.

Sources:

1. <https://www.drugs.com/drug-interactions/atorvastatin-with-aspirin-132-135-136-2113-123.html>
2. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150178/>
3. <https://www.drugpatentwatch.com/drugs/atorvastatin>