Advil is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce inflammation. The active ingredient in Advil is ibuprofen. According to the drug label [3], Advil can be taken with or without food, but it is recommended to take it with food or milk if it causes stomach upset. However, the label does not specify whether Advil can be taken with a high-fat meal.

A study published in the Journal of Pharmaceutical Sciences [2] found that the absorption of ibuprofen was delayed when it was taken with a high-fat meal. The study concluded that taking ibuprofen with a high-fat meal could decrease its bioavailability, which is the amount of the drug that enters the bloodstream and reaches the target site. However, the study did not specifically examine the effects of taking Advil with a high-fat meal.

Drug Patent Watch [1] does not provide information on whether Advil can be taken with a high-fat meal.

In summary, the drug label for Advil does not specify whether it can be taken with a high-fat meal. A study found that taking ibuprofen with a high-fat meal could decrease its bioavailability, but it did not specifically examine the effects of taking Advil with a high-fat meal. Therefore, it is recommended to take Advil with food or milk if it causes stomach upset, but it is unclear whether a high-fat meal would affect its absorption. It is recommended to consult a healthcare provider or a pharmacist for personalized advice on taking Advil with food.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191675/
[3] https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/20944_advil_biopharmr.pdf