Lyrica (pregabalin) and antidepressants are both medications that affect the central nervous system. Lyrica is an anticonvulsant drug that is used to treat nerve pain and seizures, while antidepressants are used to treat depression, anxiety, and other mental health conditions. Serotonin syndrome is a potentially life-threatening condition that can occur when there is an excess of serotonin in the body.

According to the Drug Patent Watch [1], Lyrica does not have any known drug interactions that can cause serotonin syndrome. However, it is important to note that Lyrica can cause dizziness, drowsiness, and confusion, which can be exacerbated by other medications that affect the central nervous system.

Antidepressants, on the other hand, can increase serotonin levels in the body, which can lead to serotonin syndrome if taken in combination with other medications that also increase serotonin levels. According to a study published in the Journal of Clinical Psychopharmacology [2], serotonin syndrome can occur when antidepressants are combined with other medications that affect serotonin levels, such as tramadol, St. John's Wort, and certain migraine medications.

It is important to note that not all antidepressants have the same risk of causing serotonin syndrome. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have a higher risk of causing serotonin syndrome than other types of antidepressants, such as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) [3].

In conclusion, while Lyrica does not have any known drug interactions that can cause serotonin syndrome, antidepressants can increase the risk of serotonin syndrome if taken in combination with other medications that affect serotonin levels. It is important to talk to a healthcare provider before taking any new medications, especially if you are already taking antidepressants or other medications that affect the central nervous system.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LYRICA
[2] https://www.zora.uzh.ch/id/eprint/130412/1/ZORA130412.pdf
[3] https://www.uspharmacist.com/article/drug-induced-serotonin-syndrome