Long-term use of oxycodone, a powerful opioid painkiller, can lead to several risks and complications. According to the U.S. National Library of Medicine[1], these risks include:

1. Physical dependence: Long-term use of oxycodone can lead to physical dependence, meaning that the body adapts to the presence of the drug and depends on it to function normally. If a person suddenly stops taking oxycodone, they may experience withdrawal symptoms.

2. Tolerance: Over time, the body may develop tolerance to oxycodone, meaning that higher doses are needed to achieve the same level of pain relief. This can increase the risk of overdose and other side effects.

3. Respiratory depression: Oxycodone can slow down breathing, and long-term use can increase the risk of respiratory depression, which can be life-threatening.

4. Addiction: Long-term use of oxycodone can lead to addiction, a chronic brain disorder characterized by the compulsive use of drugs despite harmful consequences.

5. Overdose: Long-term use of oxycodone can increase the risk of overdose, which can be fatal. According to DrugPatentWatch.com[2], there were 14,975 overdose deaths involving prescription opioids in the United States in 2018.

6. Other health problems: Long-term use of oxycodone can also increase the risk of other health problems, such as hormonal imbalances, urinary retention, and constipation.

It's important to note that the risks of long-term oxycodone use can vary depending on several factors, such as the dosage, the duration of use, and individual factors such as age, genetics, and overall health. If you or someone you know is taking oxycodone, it's important to follow the dosage instructions carefully, and to talk to a healthcare provider about the risks and benefits of long-term use.

Sources:

1. U.S. National Library of Medicine. Oxycodone. <https://medlineplus.gov/druginfo/meds/a682132.html>.
2. DrugPatentWatch.com. Opioid Overdose Deaths. <https://www.drugpatentwatch.com/opioid-crisis/#opioid-overdose-deaths>.