Lipitor is a brand name for the drug atorvastatin, which is used to lower cholesterol levels in the body. According to the first source [1], Lipitor is not known to interact with painkillers. However, it is important to note that different painkillers can interact with each other, so it is important to talk to a healthcare provider before taking any new medications.

The second source [2] discusses a study that found that statins, including Lipitor, can cause muscle pain and weakness in some people. This can be a concern for those who take painkillers for chronic pain, as it may reduce the effectiveness of painkillers. However, the study did not specifically look at the interaction between statins and painkillers, so more research is needed to determine the extent of this interaction.

The third source [3] offers some tips for managing muscle pain caused by statins, which may also be helpful for those who take painkillers. These tips include talking to a healthcare provider about adjusting the dosage of the statin, trying a different statin medication, and incorporating exercise and stretching into the daily routine.

In summary, while Lipitor is not known to interact with painkillers according to [1], statins such as Lipitor can cause muscle pain and weakness, which may reduce the effectiveness of painkillers according to [2]. However, more research is needed to determine the extent of this interaction. Those who experience muscle pain while taking statins may benefit from the tips for managing muscle pain offered in [3]. It is always important to talk to a healthcare provider before starting any new medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469950/
[3] https://www.health.harvard.edu/pain/managing-statin-muscle-pain