There is no clear evidence to suggest that Lipitor, a medication used to lower cholesterol levels, can enhance painkiller effectiveness. Lipitor, also known as atorvastatin, is a statin drug that works by inhibiting an enzyme that produces cholesterol in the liver [1]. While it may have some side effects, such as muscle pain, it is not commonly prescribed for pain management [3].

On the other hand, caffeine has been shown to enhance the effectiveness of some painkillers, such as aspirin and ibuprofen, by increasing their absorption and reducing the time it takes for them to take effect [2]. However, it is important to note that caffeine may not be suitable for everyone and can also have its own side effects, such as increased heart rate and insomnia [2].

In terms of managing muscle pain caused by statins, including Lipitor, Harvard Health Publishing recommends several strategies, such as switching to a different statin medication, reducing the dose, or taking a break from the medication [3]. Painkillers may also be used to manage the pain, but it is important to consult with a healthcare provider before taking any new medication or supplement.

In conclusion, while caffeine may enhance the effectiveness of some painkillers, there is no evidence to suggest that Lipitor can do the same. Managing muscle pain caused by statins such as Lipitor involves a variety of strategies and should be done under the guidance of a healthcare provider [2][3].

Sources:
[1] Drug Patent Watch. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Everyday Health. (2018, March 16). Does Caffeine Really Boost Painkiller Effectiveness? Retrieved from https://www.everydayhealth.com/pain-management/0316/does-caffeine-really-boost-painkiller-effectiveness.aspx
[3] Harvard Health Publishing. (2021, May). Managing statin muscle pain. Retrieved from https://www.health.harvard.edu/pain/managing-statin-muscle-pain