Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood [1]. It belongs to a group of drugs called statins, which work by blocking an enzyme in the liver that produces cholesterol. Lipitor is usually taken orally once a day, with or without food, and it can interact with other medications, including pain relievers.

According to WebMD [2], there are no known interactions between Lipitor and pain medications such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). However, it is important to consult with a healthcare provider before taking any new medications, including over-the-counter pain relievers, while on Lipitor.

One medication that can interact with Lipitor is ritonavir-boosted nirmatrelvir (Paxlovid), which is used to treat COVID-19 [3]. Paxlovid can increase the levels of Lipitor in the blood, which can increase the risk of side effects such as muscle pain or weakness. Therefore, it is important to inform the healthcare provider about all the medications, including over-the-counter ones, being taken before starting Lipitor.

In conclusion, Lipitor is generally safe to take with pain relievers such as acetaminophen or ibuprofen. However, it is important to consult with a healthcare provider before taking any new medications while on Lipitor, and to inform them about all the medications being taken, including over-the-counter ones.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.webmd.com/drugs/2/drug-3330/lipitor-oral/details
[3] https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/