Long-term use of Advil, a brand name for ibuprofen, can potentially cause stomach problems. Ibuprofen belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used to relieve pain, reduce inflammation, and lower fever. While Advil can be effective for short-term use, prolonged or excessive use may lead to adverse effects on the stomach and gastrointestinal (GI) system.

According to the first source, Drug Patent Watch, the prescribing information for Advil states that gastrointestinal side effects, such as stomach pain, heartburn, and indigestion, are common. These side effects can range from mild to severe, and in some cases, they may lead to more serious conditions such as ulcers, bleeding, or perforation of the stomach or intestines. It is important to note that the likelihood and severity of these side effects may vary depending on individual factors such as age, dosage, and duration of use.

The second source, GoodRx, also highlights potential side effects of Advil, including stomach pain, upset stomach, and nausea. It advises individuals to seek medical attention if they experience symptoms such as black, tarry stools, vomiting blood, or abdominal pain.

To mitigate the risk of stomach problems associated with long-term NSAID use, the third source, Hospital for Special Surgery, provides guidelines. It suggests taking the lowest effective dose for the shortest duration necessary, as well as avoiding the use of multiple NSAIDs simultaneously. The source also recommends taking the medication with food or milk to help protect the stomach lining and reduce the risk of irritation.

In conclusion, long-term use of Advil can potentially cause stomach problems. Gastrointestinal side effects are common with NSAIDs, and prolonged or excessive use may increase the risk of more serious conditions. It is advisable to follow the recommended guidelines, use the lowest effective dose for the shortest duration necessary, and consult a healthcare professional if any concerning symptoms occur.

Sources:
[1] Drug Patent Watch: https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] GoodRx: https://www.goodrx.com/advil/advil-side-effects
[3] Hospital for Special Surgery: https://www.hss.edu/conditions_guidelines-reduce-side-effects-nsaids.asp