Lipitor is a medication used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins. Grapefruit juice contains compounds that can interfere with the metabolism of certain drugs, including Lipitor. Combining Lipitor with grapefruit juice can increase the risk of side effects [2].

The active ingredient in Lipitor is atorvastatin. According to Drug Patent Watch [1], atorvastatin is metabolized by the liver's cytochrome P450 3A4 (CYP3A4) enzyme. Grapefruit juice contains compounds called furanocoumarins that can inhibit the activity of CYP3A4, which can lead to increased levels of atorvastatin in the blood. This can increase the risk of side effects associated with Lipitor, such as muscle pain, liver damage, and kidney problems.

GoodRx [2] explains that grapefruit juice can increase the absorption of atorvastatin, leading to higher levels of the drug in the bloodstream. This can increase the risk of side effects and may also reduce the effectiveness of the medication.

RO [3] recommends that people taking Lipitor avoid grapefruit juice or limit their intake. It is also important to talk to a healthcare provider about any other medications or supplements being taken, as they may also interact with Lipitor.

In conclusion, combining Lipitor with grapefruit juice can increase the risk of side effects associated with the medication. It is important to talk to a healthcare provider about any potential interactions and to avoid or limit grapefruit juice while taking Lipitor [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin
[3] https://ro.co/health-guide/lipitor-and-grapefruit/