Yes, Lipitor and antibiotics can interact negatively. Atorvastatin, the active ingredient in Lipitor, can interact with certain antibiotics, including erythromycin, clarithromycin, and telithromycin [1]. These antibiotics can increase the level of atorvastatin in the body, potentially leading to side effects such as muscle pain and liver damage [1][2]. It is essential to inform healthcare providers of all medications, including antibiotics, being taken to avoid potential negative interactions [1].

Sources:
[1] <https://www.drugs.com/drug-interactions/atorvastatin-with-erythromycin-332-1392-533-933.html>
[2] <https://www.drugpatentwatch.com/antibiotics-atorvastatin-interaction-risk-2019-05-15/>