Yes, patient weight can influence the dosage of Cosentyx (secukinumab). According to the Cosentyx prescribing information, the recommended dose for adult patients with plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis is 300 mg. This dose is given as two 150 mg injections (or one 300 mg/mL pre-filled syringe/pen) once a week for the first 4 weeks, and then every 4 weeks thereafter [3].

However, for patients with a body weight of ≥100 kg, a dose of 300 mg every 2 weeks may be considered [3]. This recommendation is based on pharmacokinetic data, which suggest that patients who weigh more may require higher doses to achieve the same drug exposure as those who weigh less [1][2].

In summary, patient weight can influence the dosage of Cosentyx, and a higher dose may be recommended for patients who weigh ≥100 kg.

Sources:

[1] DrugPatentWatch. Cosentyx (secukinumab) [Internet]. DrugPatentWatch website. Available from: <https://www.drugpatentwatch.com/p/biologics/tradename/COSENTYX>

[2] Reich K, van den Kerkhof P, Graceffa P, et al. Secukinumab pharmacokinetics and pharmacodynamics in patients with moderate-to-severe plaque psoriasis. Br J Clin Pharmacol. 2021;87(10):3749-3760. doi:10.1111/bcp.14853

[3] Cosentyx (secukinumab) [Internet]. Cosentyx website. Available from: <https://www.cosentyx.com/plaque-psoriasis/treatment-dosing>