Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce fever. Combining ibuprofen with other pain relievers may increase the risk of side effects and adverse reactions.

According to Drug Patent Watch [1], ibuprofen is often combined with other pain relievers such as acetaminophen or aspirin to enhance its effectiveness. However, taking multiple pain relievers at the same time can increase the risk of side effects such as stomach bleeding, kidney damage, and liver damage.

A study published in the National Center for Biotechnology Information [2] found that combining ibuprofen with other NSAIDs such as aspirin, naproxen, or diclofenac can increase the risk of gastrointestinal bleeding and kidney damage. The study also found that combining ibuprofen with acetaminophen can increase the risk of liver damage.

Hydrocodone and ibuprofen are often combined to relieve moderate to severe pain. According to the Mayo Clinic [3], combining these two medications can increase the risk of side effects such as dizziness, drowsiness, and difficulty breathing. It is important to follow the recommended dosage and not exceed the maximum daily dose of either medication.

In conclusion, combining ibuprofen with other pain relievers can increase the risk of side effects and adverse reactions. It is important to consult with a healthcare provider before taking multiple pain relievers at the same time. It is also important to follow the recommended dosage and not exceed the maximum daily dose of any medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/IBUPROFEN
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494203/
[3] https://www.mayoclinic.org/drugs-supplements/hydrocodone-and-ibuprofen-oral-route/description/drg-20062862