Ibuprofen, the active ingredient in Advil, has been reported to interact with certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) [1].

These interactions can lead to increased risk of bleeding, as both SSRI/SNRI antidepressants and ibuprofen can affect platelet function and increase the risk of gastrointestinal (GI) bleeding [1][2].

Additionally, concurrent use of SSRIs and Advil can lead to an increased risk of developing a condition called serotonin syndrome [1]. Serotonin syndrome is characterized by symptoms such as agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, diaphoresis, and fever [1].

It is important to note that these interactions are not guaranteed to occur in all individuals, and the risk and severity of these interactions can depend on various factors, such as the specific antidepressant being used, the dosage of ibuprofen, the duration of use, and the individual's overall health status [1].

Therefore, it is crucial for individuals taking antidepressants to consult with their healthcare provider before starting or stopping any new medications, including over-the-counter products like Advil [1].


Sources:
[1] https://www.drugpatentwatch.com/drug/ibuprofen
[2] https://www.ncbi.nlm.nih.gov/books/NBK557476/