Lipitor is a prescription medication that is used to lower cholesterol levels in the body. St. John's wort is an herbal supplement that is often used to treat depression and anxiety. While both of these medications have their own benefits, it is important to understand whether they can be taken together.

According to the drug patent watch website [1], there are no known interactions between Lipitor and St. John's wort. However, it is important to note that this does not mean that there are no potential risks associated with taking these medications together.

A study published in the Journal of Clinical Psychopharmacology [2] found that St. John's wort can significantly reduce the effectiveness of Lipitor. This is because St. John's wort can increase the metabolism of Lipitor, which can lead to lower levels of the medication in the body.

Another study published in the Journal of Clinical Pharmacology [3] found that St. John's wort can also interact with other medications that are metabolized by the liver, which includes Lipitor. This can lead to potentially dangerous side effects, such as liver damage.

In conclusion, while there are no known interactions between Lipitor and St. John's wort, it is important to be cautious when taking these medications together. It is recommended that individuals consult with their healthcare provider before taking any new medications or supplements, including St. John's wort and Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/17701167/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379774/