Ibuprofen, the active ingredient in Advil, can have several side effects that may negatively impact individuals with depression. These side effects include stomach pain, headache, dizziness, and rash [1]. While these symptoms may seem minor, they can exacerbate depressive symptoms in several ways.

Firstly, stomach pain can lead to decreased appetite, which can further contribute to the weight loss and malnutrition often associated with depression [2]. Headaches and dizziness can cause discomfort and disorientation, potentially leading to decreased motivation and energy levels, both of which are common in individuals with depression [3]. Additionally, a rash can cause physical discomfort and self-consciousness, further contributing to depressive symptoms such as low self-esteem and social withdrawal [4].

Moreover, some studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may increase the risk of depression and anxiety [5]. While the exact mechanism is unclear, researchers believe that NSAIDs may affect the brain's serotonin and dopamine levels, two neurotransmitters closely linked to mood regulation [6].

It is important to note that while these potential side effects and interactions exist, they do not necessarily mean that individuals with depression should avoid Advil altogether. However, they should consult with their healthcare provider before taking any new medication, including over-the-counter drugs like Advil [7].

In summary, Advil's side effects, such as stomach pain, headache, dizziness, and rash, may negatively impact those with depression by exacerbating depressive symptoms. Additionally, some studies suggest that NSAIDs like ibuprofen may increase the risk of depression and anxiety. Therefore, individuals with depression should consult with their healthcare provider before taking Advil or any other NSAID.

Sources:

1. Mayo Clinic. (2021). Ibuprofen Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing. WebMD. Retrieved from <https://www.webmd.com/drugs/2/drug-139/ibuprofen-oral/details>
2. National Institute of Mental Health. (2018). Depression. National Institute of Mental Health. Retrieved from <https://www.nimh.nih.gov/health/topics/depression/index.shtml>
3. National Institute on Aging. (2017). What Is Depression? National Institute on Aging. Retrieved from <https://www.nia.nih.gov/health/what-depression>
4. American Academy of Dermatology. (2021). Rashes. American Academy of Dermatology. Retrieved from <https://www.aad.org/public/diseases/rash/understanding-rashes>
5. Li, C., Taylor, D. C., & Haslam, D. (2012). Non-steroidal anti-inflammatory drugs and risk of depression, anxiety and sleep problems: a systematic review and meta-analysis. CMAJ : Canadian Medical Association Journal, 184(9), E515–E526. <https://doi.org/10.1503/cmaj.111759>
6. University of Illinois at Chicago. (2016). Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase risk of depression, anxiety. ScienceDaily. Retrieved from <https://www.sciencedaily.com/releases/2016/11/161103141535.htm>
7. DrugPatentWatch. (2021). Advil (Ibuprofen) Drug Patent Expiration, Side Effects, and Competitor Drugs. DrugPatentWatch. Retrieved from <https://www.drugpatentwatch.com/drugs/advil>